Novel biomarker discovery could lead to early diagnosis for deadly preeclampsia

  • The discovery of two new biomarkers has the potential to predict key underlying causes of preeclampsia and could lead to the early diagnosis

Sydney, Australia (July 3, 2020) — Preeclampsia is a devastating disorder that occurs very suddenly in the second half of pregnancy and causes severe health problems for both mother and baby. Preeclampsia also increases the risk of developing life-long chronic diseases such as diabetes and heart disease.

The discovery of two novel biomarkers, called FKBPL and CD44, has the potential to change the way the condition is managed according to research published in the Journal of Clinical Endocrinology and Metabolism. Preeclampsia can cause high blood pressure and organ failure in mothers and lead to preterm births and even stillbirth.

Senior author, Dr Lana McClements from the University of Technology Sydney, said the biomarkers can be used to diagnose and assess the risk of getting preeclampsia in both early and late pregnancy, „in women who otherwise appear healthy“.

„There are two main types of preeclampsia: early-onset preeclampsia diagnosed before 34 weeks of a pregnancy and late-onset preeclampsia diagnosed from 34 weeks onwards,“ Dr McClements said.

„The vast majority of the current screening and monitoring strategies are focused on early-onset preeclampsia, which comprises only 10-15 % of all preeclampsia cases, whereas late preeclampsia has been largely neglected,“ she said.

The researchers say the two biomarkers are particularly useful for diagnosing cases of late-onset preeclampsia, between the second and third trimester, a period that currently lacks reliable biomarkers.

“ The biomarkers allow the prediction of irregular placenta or maternal vascular function, which are key underlying causes of preeclampsia.

„This could lead to the early diagnosis and prevention of severe preeclampsia and associated complications including death, therefore also giving insight into disease mechanisms and possible treatment targets,“ Dr McClements said.

The research also has potential to enhance the development of therapeutics to treat preeclampsia because the increase in one of the biomarkers, FKBPL, can be inhibited by mesenchymal stem cells potentially stopping the development of preeclampsia.

“ This is why we are so excited by the discovery. In addition to their use in diagnosis, FKBPL and CD44 also show potential as drug and cell therapy targets of emerging treatments for preeclampsia, which offers hope for a future cure to this terrible disorder,“ Dr McClements said.

Other institutions involved in the research are Queen’s University Belfast, UK; Medical University Graz, Austria; Royal College of Surgeons in Ireland, Ireland; University College Cork, Ireland; University of Liverpool, UK; University of Belgrade, Serbia; The Hashemite University, Jordan; Mayo Clinic, USA; Belfast Health and Social Care Trust, UK

 


University of Technology Sydney, 03.07.2020 (tB).

Schlagwörter: ,

MEDICAL NEWS

IU School of Medicine researchers develop blood test for anxiety
COVID-19 pandemic increased rates and severity of depression, whether people…
COVID-19: Bacterial co-infection is a major risk factor for death,…
Regenstrief-led study shows enhanced spiritual care improves well-being of ICU…
Hidden bacteria presents a substantial risk of antimicrobial resistance in…

SCHMERZ PAINCARE

Hydromorphon Aristo® long ist das führende Präferenzpräparat bei Tumorschmerz
Sorgen und Versorgen – Schmerzmedizin konkret: „Sorge als identitätsstiftendes Element…
Problem Schmerzmittelkonsum
Post-Covid und Muskelschmerz
Kopfschmerz bei Übergebrauch von Schmerz- oder Migränemitteln

DIABETES

Wie das Dexom G7 abstrakte Zahlen mit Farben greifbar macht…
Diabetes mellitus: eine der großen Volkskrankheiten im Blickpunkt der Schmerzmedizin
Suliqua®: Einfacher hin zu einer guten glykämischen Kontrolle
Menschen mit Diabetes während der Corona-Pandemie unterversorgt? Studie zeigt auffällige…
Suliqua® zur Therapieoptimierung bei unzureichender BOT

ERNÄHRUNG

Positiver Effekt der grünen Mittelmeerdiät auf die Aorta
Natriumaufnahme und Herz-Kreislaufrisiko
Tierwohl-Fleisch aus Deutschland nur mäßig attraktiv in anderen Ländern
Diät: Gehirn verstärkt Signal an Hungersynapsen
Süßigkeiten verändern unser Gehirn

ONKOLOGIE

Strahlentherapie ist oft ebenso effizient wie die OP: Neues vom…
Zanubrutinib bei chronischer lymphatischer Leukämie: Zusatznutzen für bestimmte Betroffene
Eileiter-Entfernung als Vorbeugung gegen Eierstockkrebs akzeptiert
Antibiotika als Störfaktor bei CAR-T-Zell-Therapie
Bauchspeicheldrüsenkrebs: Spezielle Diät kann Erfolg der Chemotherapie beeinflussen

MULTIPLE SKLEROSE

Multiple Sklerose: Aktuelle Immunmodulatoren im Vergleich
Neuer Biomarker für Verlauf von Multipler Sklerose
Multiple Sklerose: Analysen aus Münster erhärten Verdacht gegen das Epstein-Barr-Virus
Aktuelle Daten zu Novartis Ofatumumab und Siponimod bestätigen Vorteil des…
Multiple Sklerose durch das Epstein-Barr-Virus – kommt die MS-Impfung?

PARKINSON

Meilenstein in der Parkinson-Forschung: Neuer Alpha-Synuclein-Test entdeckt die Nervenerkrankung vor…
Neue Erkenntnisse für die Parkinson-Therapie
Cochrane Review: Bewegung hilft, die Schwere von Bewegungssymptomen bei Parkinson…
Technische Innovationen für eine maßgeschneiderte Parkinson-Diagnostik und Therapie
Biomarker und Gene: neue Chancen und Herausforderungen für die Parkinson-Diagnose…