Oral nutritional interventions improve nutritional intake and QOL in malnourished cancer patients

 

Oxford, UK (February 15, 2012) – Oral nutritional interventions help increase nutritional intake and improve some aspects of quality of life (QOL) in malnourished cancer patients or those who are at nutritional risk, but do not effect mortality, according to a study published February 15 in the Journal of the National Cancer Institute.

 

The American Cancer Society estimated 12 million new cancer diagnoses worldwide in 2007, expecting this to more than double in the next 50 years. While international guidelines have suggested a nutritional intervention with dietary advice and/or oral nutritional supplements for malnourished cancer patients or in cancer patients who are at nutritional risk in the past, these suggestions are based largely on expert opinion as opposed to clinical trials.

 

In order to determine the effectiveness of oral nutritional interventions on the QOL of malnourished cancer patients and those who are at nutritional risk, Christine Baldwin, Ph.D., RD, Lecturer at the Nutritional Sciences Division at King’s College in London and colleagues, electronically searched several databases for randomized control trials (RCTs) of cancer patients who were malnourished or at risk of malnutrition and receiving oral nutritional support compared to patients who received routine care. The researchers examined 13 studies for a total of 1,414 patients. They measured the mortality, weight, energy intake, and QOL of patients taking nutritional interventions compared to those on routine care.

 

The researchers found that nutritional intervention resulted in a wide range of effects on both weight and energy intake. The researchers also found statistically significant improvements in aspects of QOL such as emotional functioning, dyspnea, and loss of appetite. But the nutritional intervention had no influence on mortality.

 

"The findings suggest that oral nutritional interventions have no effect on survival and that the effect on body weight and energy intake is inconsistent but that statistically significant improvements in some aspects of QOL may be achieved," the researchers write. Despite these findings, the researchers note the limitations of the study, namely the heterogeneity of the studies—both clinically and statistically. They conclude, "It is not possible, therefore, to explain the difference found between studies, but it is likely that the factors such as site and stage of disease and indeed variations in the duration, nature, and intensity of the nutritional intervention will account for difference in effects in patients."

 

In an accompanying editorial, Ann O’Mara, Ph.D., RN, and Diane St. Germain, MS, RN of the Division of Cancer Prevention at the National Cancer Institute write that malnutrition can independently predict poor outcomes with cancer treatment, but that not all patients will benefit from oral nutritional support either in improved survival or in QOL. They feel that oral nutrition supplements are suggested because they are perceived to come without negative side effects. "Dietary counseling may be beneficial for patients at high risk for malnutrition and their caregivers," the editorialists write. They also feel that since the research contains limitations, it’s challenging to apply the findings to practice. "Until future research provides clearer answers regarding who will benefit from nutritional interventions, the use of a comprehensive assessment, published nutritional guidelines, and early interventions are essential."

 

 


Journal of the National Cancer Institute, 15.02.2012 (tB).

MEDICAL NEWS

IU School of Medicine researchers develop blood test for anxiety
COVID-19 pandemic increased rates and severity of depression, whether people…
COVID-19: Bacterial co-infection is a major risk factor for death,…
Regenstrief-led study shows enhanced spiritual care improves well-being of ICU…
Hidden bacteria presents a substantial risk of antimicrobial resistance in…

SCHMERZ PAINCARE

Hydromorphon Aristo® long ist das führende Präferenzpräparat bei Tumorschmerz
Sorgen und Versorgen – Schmerzmedizin konkret: „Sorge als identitätsstiftendes Element…
Problem Schmerzmittelkonsum
Post-Covid und Muskelschmerz
Kopfschmerz bei Übergebrauch von Schmerz- oder Migränemitteln

DIABETES

Wie das Dexom G7 abstrakte Zahlen mit Farben greifbar macht…
Diabetes mellitus: eine der großen Volkskrankheiten im Blickpunkt der Schmerzmedizin
Suliqua®: Einfacher hin zu einer guten glykämischen Kontrolle
Menschen mit Diabetes während der Corona-Pandemie unterversorgt? Studie zeigt auffällige…
Suliqua® zur Therapieoptimierung bei unzureichender BOT

ERNÄHRUNG

Positiver Effekt der grünen Mittelmeerdiät auf die Aorta
Natriumaufnahme und Herz-Kreislaufrisiko
Tierwohl-Fleisch aus Deutschland nur mäßig attraktiv in anderen Ländern
Diät: Gehirn verstärkt Signal an Hungersynapsen
Süßigkeiten verändern unser Gehirn

ONKOLOGIE

Strahlentherapie ist oft ebenso effizient wie die OP: Neues vom…
Zanubrutinib bei chronischer lymphatischer Leukämie: Zusatznutzen für bestimmte Betroffene
Eileiter-Entfernung als Vorbeugung gegen Eierstockkrebs akzeptiert
Antibiotika als Störfaktor bei CAR-T-Zell-Therapie
Bauchspeicheldrüsenkrebs: Spezielle Diät kann Erfolg der Chemotherapie beeinflussen

MULTIPLE SKLEROSE

Multiple Sklerose: Aktuelle Immunmodulatoren im Vergleich
Neuer Biomarker für Verlauf von Multipler Sklerose
Multiple Sklerose: Analysen aus Münster erhärten Verdacht gegen das Epstein-Barr-Virus
Aktuelle Daten zu Novartis Ofatumumab und Siponimod bestätigen Vorteil des…
Multiple Sklerose durch das Epstein-Barr-Virus – kommt die MS-Impfung?

PARKINSON

Meilenstein in der Parkinson-Forschung: Neuer Alpha-Synuclein-Test entdeckt die Nervenerkrankung vor…
Neue Erkenntnisse für die Parkinson-Therapie
Cochrane Review: Bewegung hilft, die Schwere von Bewegungssymptomen bei Parkinson…
Technische Innovationen für eine maßgeschneiderte Parkinson-Diagnostik und Therapie
Biomarker und Gene: neue Chancen und Herausforderungen für die Parkinson-Diagnose…