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Researchers find increase in infection rates in patients with cardiac electrophysiological devices

Pacemakers and implantable cardioverter defibrillators studied in 16-year analysis of infection trends

Philadelphia, Pennsylvania, USA (August 18, 2011) – New research from the Jefferson Heart Institute shows that patients in the United States who receive cardiac electrophysiological devices (CIEDs), including permanent pacemakers and implantable cardioverter-defibrillators (ICDs) are now at greater risk of contracting an infection over the life span of the device.

Jefferson, in collaboration with researchers from Drexel University School of Biomedical Engineering and engineering and consulting firm Exponent, analyzed data from the Nationwide Inpatient Sample—a national database of hospital discharge records—from 1993-2008 and found a significant increase in CIED-related infections. Their findings are published in the August 30 issue of the Journal of the American College of Cardiology.

Their analysis found that the annual incidence of CIED-related infection increased by 210 percent over the 16-year period studied.

Further analysis showed a jump in infections after 2004, directly correlating with an increase in four major comorbidities: renal failure, respiratory failure, heart failure and diabetes.

"We believe the growing number of clinical comorbidities in this patient population plays a large role in the increase in infections associated with CIEDs," said Arnold J. Greenspon, M.D., professor of medicine at Jefferson Medical College of Thomas Jefferson University, director of Cardiac Electrophysiology at Thomas Jefferson University Hospital, and lead author of the study. "The patients are sicker, which may place them at higher risk for infection." The highest infection rates occurred in white males over 65.

Pacemakers and ICDs are important in regulating the electrical signaling to the heart. Pacemakers help to speed up a slow heart rhythm (bradycardia) whereas ICDs help to slow down rapid heart rhythm (tachycardia), a potentially life-threatening condition.

The study showed a 96 percent increase in CIED implantation, mostly due to a marked increase in the use of ICDs. "The expanding indications for ICD implantation may have contributed to the rise in infections since many of these patients have multiple medical co-morbidities," added Dr. Greenspon.

"The number of Americans receiving pacemakers and defibrillators has dramatically increased. This analysis shows that the infection risk associated with these devices has, unfortunately, increased as well," said Greenspon. A better understanding of the risk factors for infection will improve patient care and, hopefully, reduce the prolonged hospital stays that often result.

Rising CIED infection rates also have economic implications for hospitals, as these patients require prolonged hospital stays which are associated with increased costs.

Further investigation into the risk factors that predict CIED infection or therapies to mitigate this issue is warranted.

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• Other authors include Daniel R. Frisch, MD, assistant professor of Medicine and director of Jefferson’s Atrial Fibrillation program; Reginald T. Ho, MD, clinical assistant professor of Cardiology; and Behzad B. Pavri, MD, associate professor of Cardiology.

• Thomas Jefferson University, the largest freestanding academic medical center in Philadelphia, is composed of Jefferson Medical College, Jefferson College of Graduate Studies, Jefferson School of Population Health, Jefferson School of Health Professions, Jefferson School of Pharmacy, and Jefferson School of Nursing. Jefferson is regarded nationally as one of the best universities offering a range of comprehensive programs for the education of health professions. Thomas Jefferson University partners with Thomas Jefferson University Hospital, its education and clinical care affiliate.

Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 22.08.2011 Nursing News (tB).